The New York Knicks take the court against the Cleveland Cavaliers as just 2.5-point favorites in the first game of the 2025-26 NBA season for both teams on Wednesday, October 22, 2025 at 7 p.m. ET on ESPN and MSG.
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Listen to the game on ESPN New York
Knicks vs. Cavaliers Predictions for Wednesday
Our computer projections model for this contest calls for a final score of Cavaliers 117, Knicks 113.
- Moneyline Pick: Cavaliers (+121)
- Total Pick: Over 228.5 (computer predicts 229.8 points)
- Pick ATS: Cavaliers (+2.5)
Recent Knicks vs. Cavaliers Matchups
| Date | Favorite | Spread | Total | Favorite Moneyline | Underdog Moneyline | Result |
|---|---|---|---|---|---|---|
| 4/11/2025 | Knicks | -2 | 223.5 | -149 | +125 | 108-102 CLE |
| 4/2/2025 | Cavaliers | -10.5 | 231.5 | -515 | +389 | 124-105 CLE |
| 2/21/2025 | Cavaliers | -7.5 | 241.5 | -296 | +238 | 142-105 CLE |
| 10/28/2024 | Knicks | -3 | 222.5 | -142 | +121 | 110-104 CLE |
Knicks 2024-25 Betting Trends
- New York had 40 wins in 82 games against the spread last year.
- The Knicks' ATS record as 2.5-point favorites or more was 30-27-1 last season.
- Out of 82 New York games last year, 42 hit the over.
- The Knicks won 72.3% of the games last season in which they were favored on the moneyline (47-18).
- New York had a record of 42-15 in games it played as a moneyline favorite with odds of -143 or shorter last year (73.7%).
Cavaliers 2024-25 Betting Trends
- Cleveland compiled a 48-33-1 record against the spread last year.
- The Cavaliers went 3-2 as underdogs of 2.5 points or more last season.
- Last year 50 of Cleveland's games went over the point total.
- The Cavaliers were underdogs in eight games last season and won four (50%) of those contests.
- Last season, Cleveland won one of its four games when it was the underdog by at least +121 on the moneyline.
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Knicks vs. Cavaliers Injury Report
Knicks
Knicks: None
Cavaliers
Cavaliers:
Darius Garland: Out (Toe)
Knicks vs. Cavaliers Game Time and TV Channel
- Game day: Wednesday, October 22, 2025
- Game time: 7 p.m. ET
- TV channel: ESPN and MSG
- Location: New York City, New York
- Arena: Madison Square Garden
- Live stream: Watch this game on Fubo (Regional restrictions may apply)
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