The Penn State Nittany Lions (3-6) take on a fellow Big Ten foe when they visit the Michigan State Spartans (3-6) on Saturday, November 15, 2025 at Spartan Stadium.
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Penn State vs. Michigan State Matchup Info
- Game date: Saturday, November 15, 2025
- Game time: 3:30 p.m. ET
- Location: East Lansing, Michigan
- Venue: Spartan Stadium
- TV channel: CBS
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Penn State vs. Michigan State Odds and Prediction
- Spread favorite: Nittany Lions (-7)
- Moneyline: Nittany Lions (-267), Spartans (+217)
- Total: 49.5 points
- Pick ATS: Michigan State (+7)
- Pick OU: Over (49.5)
- Prediction: Penn State 29, Michigan State 25
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Penn State vs. Michigan State Betting Records and Insights
- Penn State has a record of just 2-7-0 against the spread this season.
- Michigan State has won five games against the spread this year, failing to cover four times.
- The Nittany Lions have not covered the spread this season (0-5 ATS) when playing as at least 7-point favorites.
- When playing as at least 7-point underdogs this season, the Spartans have an ATS record of 4-0.
- A total of seven out of nine Penn State games this season have gone over the point total.
- So far this season, six of Michigan State's nine games with a set number have gone over the point total.