The Penn State Nittany Lions (3-2) and the Northwestern Wildcats (3-2) square off on Saturday, October 11, 2025 at West Shore Home Field at Beaver Stadium in a clash of Big Ten foes.

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Penn State vs. Northwestern Matchup Info

Game date: Saturday, October 11, 2025
Game time: 3:30 p.m. ET
Location: University Park, Pennsylvania
Venue: West Shore Home Field at Beaver Stadium
TV channel: Fox Sports 1
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Penn State vs. Northwestern Odds and Prediction

Spread favorite: Nittany Lions (-21.5)
Moneyline: Nittany Lions (-1887), Wildcats (+998)
Total: 48.5 points
Pick ATS: Northwestern (+21.5)
Pick OU: Under (48.5)
Prediction: Penn State 24, Northwestern 23

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Penn State vs. Northwestern Betting Records and Insights

Penn State has put together a 0-5-0 record against the spread this season.
Northwestern is 3-2-0 ATS this season.
The Nittany Lions have not covered the spread when favored by 21.5 points or more this season (in four opportunities).
The Wildcats have covered the spread when playing as at least 21.5-point underdogs in their only opportunity this season.
A total of four out of five Penn State games this season have gone over the point total.
So far this season, two Northwestern games have hit the over.